MAGEs in brain

Brain-specific mage genes and neurodevelopmental disorders.

Several of the type II MAGEs are
enriched in the brain, but for many of them, nothing is known about their function. First insights suggest that they follow the common thread of promoting faster adaptation to stress and changes in the environment. We seek to uncover their molecular, cellular, and physiological roles and if and how they contribute to the pathogenesis of neurodevelopmental diseases. At this time, we study MAGEL2 and its role in different syndromes, including Prader-Willi, Schaaf-Yang, and Chitayat-Hall.

Current projects goals are:

  • Discover the molecular mechanisms of MAGEL2 function in the hypothalamus on a single-cell level.
  • Determine the function of MAGEL2 pathological mutations, found in the SYS patients.
  • Comparative analysis of MAGEL2 and its role in animals.

Relevant publications:

  • Hao et al., Cell 2013
  • Hao et al., Mol Cell 2015
  • Fon Tacer and Potts, Biochem J 2017
  • Chen et al., JCI Insight 2020

The figure depicts a phylogenetic tree showing the relationship between human and mouse MAGE proteins.