Fon Tacer Lab
Fon Tacer Lab
Slide 1


Welcome to the Fon Tacer Lab

at the Texas Tech University
School of Veterinary Medicine.

Slide 1


Welcome to the Fon Tacer Lab

at the Texas Tech University
School of Veterinary Medicine.

previous arrow
next arrow

We investigate tissue-specific mechanisms that evolved in mammals to protect cells against stress. We want to understand why and how these pathways get hijacked in cancer or dysregulated in different diseases. To address these questions, we use genes with unique tissue-specific expressions as a handle. We aim to determine their function in humans and animals with comparative and multidisciplinary approaches.

Our favorite genes are melanoma antigens (MAGEs) and γKlotho, whose expression is restricted to the testis or brain and eye lens, respectively. We envision that our research will help advance fertility preservation and cancer therapy for human and animal patients.

Germ cells and cancer

With our projects at the crossroads of spermatogenesis and cancer, we want to identify the mechanisms behind the stress-protective function of type I melanoma antigens (MAGEs). Type I MAGEs are proteins ....

read more

MAGEs in brain

Several of the type II MAGEs are enriched in the brain, but for many of them, nothing is known about their function. First insights suggest that they follow the common thread of promoting faster adaptation to stress and changes in the environment.

read more

γKlotho and cancer

Klotho proteins were discovered as coreceptors for endocrine fibroblast growth factors. Given their role in metabolism, the bonafide members of the Klotho family, αKlotho and βklotho act as tumor suppressors in cancer.

read more

Meet The P.I.

Contact Information

    Klementina Fon Tacer, DVM, PhD

    Biography

    In 2020, Klementina joined the faculty of the School of Veterinary Medicine at the Texas Tech University (TTU SVM) and became a Cancer Prevention and Research Institute of Texas (CPRIT) Scholar. She is a Director of the Texas Center for Comparative Cancer Research at the TTU SVM and holds a secondary appointment in the Department of Biology and an adjunct position at the Texas Tech University Health Science Center.

    Klementina received her D.V.M. and Ph.D. degrees from the University of Ljubljana, Slovenia, where she was trained in veterinary medicine, molecular biology, and biochemistry. During her Ph.D. studies, she became fascinated with germ cells and their specific ways to regulate metabolism. She came to the U.S. for her post-doctoral training at the University of Texas

    Reflecting and Looking Forward – The Role of Veterinary Scientific Journals in Veterinary Research and Medicine

    Klementina Fon Tacer

    A 2023 Nobel Prize in Physiology or Medicine: Pathway for Next Generation of Vaccines

    Uroš Rajčevič, Klementina Fon Tacer

    PWS-Associated Genes, Their Imprinting, and Expression Pattern

    Maria Camila Hoyos Sanchez, Tara Bayat, Rebecca R Florke Gee, Klementina Fon Tacer

    Cell-specific secretory granule sorting mechanisms: the role of MAGEL2 and retromer in hypothalamic regulated secretion

    Denis Štepihar, Rebecca R Florke Gee, Maria Camila Hoyos Sanchez, Klementina Fon Tacer
    View all Publications